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For over 30 years, Best Friends Animal Society has been running the nation’s largest no-kill sanctuary for companion animals and building effective programs that reduce the number of animals entering shelters. The mission of Best Friends Animal Society is to bring about a time when there are No More Homeless Pets. The organization does this by helping end the killing in America's animal shelters through building community programs and partnerships all across the United States.

Breast cancer is a complex disease with no simple solution. Research is the key to stopping it in its tracks. Founded in 1993 by Evelyn H. Lauder, the Breast Cancer Research Foundation (BCRF) is the largest private funder of breast cancer research in the world. We invest in the best minds in science—and foster cross-disciplinary collaboration—to examine every aspect of the disease from prevention to metastasis. Our approach accelerates the entire field and moves us closer to the answers we urgently need. We can’t stop now. Join us in fueling the world’s most promising research. With you, we will bring the end of breast cancer into focus. Learn more and get involved at BCRF.org.

Memorial Sloan-Kettering Cancer Center is dedicated to leading the fight against cancer, individually focusing on each patient and creating an impact on cancer treatment and the biomedical research agenda around the world. As one of the world's premier cancer centers, Memorial Sloan Kettering Cancer Center is committed to exceptional patient care, leading-edge research, and superb educational programs. The close collaboration between its physicians and scientists is one of its unique strengths, enabling it to provide patients with the best care available today as we work to discover more effective strategies to prevent, control, and ultimately cure cancer in the future.

GlobalGiving makes it possible for anyone to give to community-led nonprofits all over the world. Our mission is to transform aid and philanthropy to accelerate community-led change. We make it possible for you to support local projects in 170 countries, giving nonprofits access to the funding, tools, and training they need to become more effective and to make our world a better place.

Airlink is a global humanitarian organization delivering critical aid to communities in crisis by providing airlift and logistical solutions to nonprofit partners, changing the way the humanitarian community responds to disasters around the world. Our funding comes from donations and in-kind awards from airlines, aviation sector businesses, foundations, and individuals. We build long-term relationships with airlines, who provide Airlink with access to airlift to harness the power and speed of aviation to deliver humanitarian aid and responders in the wake of natural or man-made disasters. Airlink ensures the right aid gets to communities in need at the right time.

Global Empowerment Mission (GEM) acts as a first responder to vulnerable communities affected by disasters around the world. GEM is dedicated to restoring hope and opportunity in the lives of those most affected by disasters. The organization provides immediate relief, assists communities during the gap period before receiving assistance from other institutions, and engages in long-term recovery efforts with sustainable development practices. This three-phased approach allows GEM to provide individuals and families with the help they need when they need it most.

Americares helps people and communities around the world access health in times of disaster and every day. Americares is a health-focused relief and development organization that saves lives and improves health for people affected by poverty or disaster. Each year, Americares reaches 85 countries on average, including the United States, with life-changing health programs, medicine, medical supplies and emergency aid. Americares is one of the world’s leading nonprofit providers of donated medicine and medical supplies. For 45 years, we have met the health needs of our local partners and their communities. Our donors make it possible to get medicine and critical care to families and communities in need

CARE is a leading humanitarian organization fighting global poverty. We place special focus on working alongside poor women because, equipped with the proper resources, women have the power to help whole families and entire communities escape poverty. Women are at the heart of CARE's community-based efforts to improve basic education, prevent the spread of HIV, increase access to clean water and sanitation, expand economic opportunity and protect natural resources. CARE also delivers emergency aid to survivors of war and natural disasters, and helps people rebuild their lives.

Direct Relief improves the health and lives of people affected by poverty or emergency situations by mobilizing and providing essential medical resources needed for their care. Direct Relief works in all 50 U.S. states and in more than 90 countries to expand access to medicine and healthcare by equipping doctors and nurses with lifesaving medical resources.

Oceana, the world's largest international organization focused exclusively on ocean conservation, was founded in 2001 by a group of leading foundations concerned that although the oceans constitute over 70 percent of the earth's surface, an extremely small percentage of environmental funding was dedicated to protecting them.  Oceana's campaigns are designed to change that by forcing clear, identifiable policy changes with real "in the water" results, usually in three to five years. Our international campaigns in North America, Europe, Chile, and Belize are focused on the actions agreed on by scientists throughout the world as necessary to preserve and restore marine life: Protect seafloor habitat from destructive bottom trawling; Set and enforce reasonable catch limits for commercial fishing; Stop subsidizing overcapacity in commercial fishing fleets; Stop marine pollution, particularly carbon dioxide emissions that are making the oceans more acidic; Oceana sets annual goals toward achieving specific changes and holds itself strictly accountable to its Board, funders, and supporters.  Since inception, Oceana has achieved dramatic success in protecting the world's oceans in targeted, practical ways.

The National Multiple Sclerosis Society's mission is to cure multiple sclerosis while empowering people affected by multiple sclerosis (MS) to live their best lives. The organization pledges to accelerate cures through global leadership, and improve access to personalized, affordable, high-quality MS healthcare. It empowers people affected by MS to solve everyday challenges and strengthens the MS movement through more and deeper connections.

Motherhood in the U.S. should not be this hard. Chamber of Mothers is a nonpartisan 501(c)(3) uniting mothers as advocates to create a better America. Through grassroots movements, local chapters, strategic communication, and community-building, Chamber of Mothers unites mothers as advocates to create the country we want to live in and bestow upon future generations. We need YOU in this movement. Chamber of Mothers is currently an all-volunteer effort, built and run while operating businesses, feeding babies, folding laundry, and doing the carework that fuels the U.S. economy. Changing the lives of 85 million U.S. mothers doesn’t happen without financial resources. Fuel the mission and make a tax-deductible donation today.